Literature summary extracted from
Kudo, N.R.; Anger, M.; Peters, A.H.; Stemmann, O.; Theussl, H.C.; Helmhart, W.; Kudo, H.; Heyting, C.; Nasmyth, K.
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I (2009), J. Cell Sci., 122, 2686-2698.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.4.22.49 |
the active (S1126A/T1346A) and the inactive (C1129S) separase mutants are coexpressed in HEK-293T cells with human securin |
Homo sapiens |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.4.22.49 |
C1129S |
inactive |
Homo sapiens |
3.4.22.49 |
S1126A/T1346A |
active mutant |
Homo sapiens |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.4.22.49 |
securin |
- |
Homo sapiens |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.22.49 |
Homo sapiens |
- |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
3.4.22.49 |
- |
Homo sapiens |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
3.4.22.49 |
Rec8 + H2O |
Rec8 is a meiosis-specific alpha-kleisin subunit of cohesion, phosphorylation by polo-like kinase 1 of either Rec8 or separase, or both, promotes Rec8 cleavage. Separase prefers to cleave at R454 |
Homo sapiens |
fragments of Rec8 |
- |
? |
|
3.4.22.49 |
Scc1 + H2O |
Scc1 is an alpha-kleisin subunit of cohesin |
Homo sapiens |
fragments of Scc1 |
- |
? |
|